GENETIC INFLAMMATORY DISEASE LIBRARY
Genetic inflammatory disease is not one diagnosis. It is a pattern: inherited pathway weaknesses, inflammatory signaling, methylation stress, detoxification burden, nutrient transport problems, and immune overactivation interacting with real-world triggers.
Dr. Purser’s work connects symptoms to mechanisms: homocysteine, PEMT and choline demand, MTHFR and methylation strain, cytokine axes, mast-cell activation, liver inflammation, autoimmune signaling, and intracellular nutrient deficits.
Each cluster can become a standalone guide, video, diagram, and patient education article — all internally linked back to this authority hub.
MTHFR + HOMOCYSTEINE
Core search hub for MTHFR symptoms treatment, homocysteine testing, methylation support, cardiovascular inflammation, neurological inflammation, and fatigue patterns.
PEMT + CHOLINE
A natural cluster for PEMT gene mutation, choline deficiency liver problems, NAFLD risk, gallbladder patterns, phosphatidylcholine, and inflammatory metabolism.
CYTOKINES
The cytokine cluster supports articles on inflammatory bowel disease, alpha-gal, CIRS, skin inflammation, joint pain, fatigue, autoimmune signaling, and post-infectious inflammation.
MAST CELLS
A patient-language bridge for unexplained reactions, flushing, gut symptoms, skin flares, brain fog, and immune overactivation that often sits between allergy and inflammation.
CIRS + DETOXIFICATION
Supports future pages on CIRS cytokines, mold-related inflammation, glutathione, liver phase pathways, HLA patterns, neurological symptoms, and post-exposure relapse.
AUTOIMMUNE TRIGGERS
This cluster can capture searches around autoimmune flares, inflammatory bowel disease, skin disease, thyroid patterns, connective tissue disease, and systemic inflammatory pain.
For patients searching why normal labs do not explain fatigue, cognitive changes, post-exertional crashes, pain, or neurological symptoms.
A hub for ulcerative colitis, Crohn’s-like inflammation, IL-23 signaling, TNF-alpha, gut barrier issues, and immune tolerance failures.
For lichen planus, CREST-like patterns, rashes, swelling, connective tissue inflammation, and immune reactions that require pathway-level thinking.